For me LDN helped a little bit with everything across the board, but it did not improve anything very much. Most noticeably it decreased pain and inflammation in my face and head. Not a miracle worker but a solid first-line treatment.

LDN about 6 months. Unsure if it has helped anything. Started it with Metformin and also extra oral supplents. But my condition has improved only minimally if at all. I do know that it doesn't make anything "worse". O could possibly say I'm more aware in the moment but that turns in to the same short term memory loss very soon and cognitive deficits remain. One extra side effect I would add is severe lack of appetite, distaste for food or anorexia (non psychological form).

I responded well to LDN from the first dose. Helped my brain fog a lot & a little with fatigue. Truly gave me some life back when I had lost hope. I felt like I couldn't think & making decisions was hard. Finding the right dosage seems to be tricky for some - Titrating up to 4mg from 1mg to 2mg took months/year for me. I had weird dreams from it but that's all for side effects except when titrating it made me jittery/anxious/frazzled when I went up too fast. Overall it's been good for me & I notice when I miss a couple days. Helps me think clearer & have better mood. I got good grades growing up, wrote for fun/work & still struggle with feeling like I can't express what feels like thoughts that are fully formed but behind glass sometimes. LDN is worth a try if you're considering. My long covid doc said 50/50 helps long covid & is relatively low risk side effects wise. I've been on it for nearly 2 years now.

Although it helped control CRPS pain, it did nothing for my ME or LC. It did not help with fatigue, PEM/PENE, or any cognitive impairment. LDN is a very individual drug. It doesn’t help everyone and, in Australia, it is quite expensive. It is worth trying IMHO, but it’s not the wonder drug many people think it is.

takes awhile to have an effect, for me about 2 months. Best prescription drug for Long Covid. https://suomencovi­dyhdistys.fi/

This drug gave me night terrors and made me very wired during the day. I tried 0.5mg a day for about a week, two separate times months apart. For me, saw no noticeable benefit just unwanted sixe effects.

I started LDN at 0.5mg and gradually increased my dose to 6mg over about 7 months. During this time, my Long COVID heart symptoms (which included stabbing chest pain and palpitations) gradually receded. I also found that it benefitted me in other ways. For example, even before developing Long COVID, I had some digestion problems that bothered me for most of my life. I noticed that these went away when using LDN and didn't come back so long as I kept taking it. Also, when I first started using LDN, it significantly reduced my appetite, and I lost about 5 lbs. Unfortunately, this only lasted for about a month. It was quite hard to start taking LDN--I had almost unbearable brain fog for about 5 days when I first began taking it, and I experienced severe fatigue crashes. This happened every time I increased my dosage, although it got less severe over time. My wife asked me to warn her when I was increasing my dosage, as it made me very irritable. Thankfully, these effects didn't last. I still take LDN today and will probably take it long-term even if I fully recover from Long COVID because of the improved digestion.

Low Dose Naltrexone (LDN), has greatly helped with my profound fatigue and post-exert­ional malaise symptoms and helps many Long Covid patients. My optimal dose has been around 2.5mg, but the typical dose is 4.5mg per day (I've heard of co-workers taking higher doses, though, like 11mg). Make sure to start “low and slow,” around 1mg or lower, increasing the dose every few weeks. You can get the drug as a liquid solution so it’s easier to find the dose that works best for you. If it hurts your stomach, take it with food or ask for the drug in a lotion. I take it in the morning because it can keep me awake if I take it at night. To fill a prescription for LDN, you’ll probably need your doctor to send the prescription to a special kind of pharmacy called a compounding pharmacy. In San Francisco, I use Koshland Pharmacy. LDN is also available from AgelessRx.

My fatigue slowly lessened. This won’t help with lack of sleep, but horrible fatigue, yes! My Dr ordered 50 mg Naltrexone (free in California) twice a day to combat crippling fatigue. I started with 25 mg once a day for 2 weeks, then increased to 50 mg. I’ve taken it for 14 months.

LDN bumped me from moderate to mild and kept me there for months. I had a crash from minor surgery a few months after I started it and it didn’t keep that from happening, but I’m almost fully recovered now after a month, and I do think that improvement time is likely helped my keeping up the LDN.