Low Dose Naltrexone (LDN), has greatly helped with my profound fatigue and post-exert­ional malaise symptoms and helps many Long Covid patients. My optimal dose has been around 2.5mg, but the typical dose is 4.5mg per day (I've heard of co-workers taking higher doses, though, like 11mg). Make sure to start “low and slow,” around 1mg or lower, increasing the dose every few weeks. You can get the drug as a liquid solution so it’s easier to find the dose that works best for you. If it hurts your stomach, take it with food or ask for the drug in a lotion. I take it in the morning because it can keep me awake if I take it at night. To fill a prescription for LDN, you’ll probably need your doctor to send the prescription to a special kind of pharmacy called a compounding pharmacy. In San Francisco, I use Koshland Pharmacy. LDN is also available from AgelessRx.

My immunologist and allergist both recommended the use of non-drowsy antihistamines for Long Covid, and they recommended Allegra and Xyzal. My allergist said to take up to 4 pills per day of either (or mix and match them). I take two pills twice a day (4 pills total per day), and it greatly helps with my overall sense of wellness and with all allergy-like symptoms.

I've tried other similar supplements (nattokinase, serrapeptase) that had no apparent effect other than causing my immune system to rev up. But the lumbrokinase supplement from Allergy Research Group helped with my cognitive symptoms, including information processing and memory. I can read for pleasure again, which means a lot to me. Because lumbrokinase can cause immune activation, I took just one capsule daily while I was taking it.