Low Dose Naltrexone (LDN), has greatly helped with my profound fatigue and post-exert­ional malaise symptoms and helps many Long Covid patients. My optimal dose has been around 2.5mg, but the typical dose is 4.5mg per day (I've heard of co-workers taking higher doses, though, like 11mg). Make sure to start “low and slow,” around 1mg or lower, increasing the dose every few weeks. You can get the drug as a liquid solution so it’s easier to find the dose that works best for you. If it hurts your stomach, take it with food or ask for the drug in a lotion. I take it in the morning because it can keep me awake if I take it at night. To fill a prescription for LDN, you’ll probably need your doctor to send the prescription to a special kind of pharmacy called a compounding pharmacy. In San Francisco, I use Koshland Pharmacy. LDN is also available from AgelessRx.