Positives

• “Unlocked energy”: several Long COVID/ME /CFS users on r/Mounjaro say tirzepatide let them work full days and lift weights again without post-exertional crashesReddit

• Steady weight loss (≈12 kg) has eased joint pain and daily body aches for some ME /CFS posters, who call the drug “worth it even if fatigue hasn’t budged yet”Reddit

• Low-dose (3.5 mg) weekly shots yielded “very limited side-effects” while smoothing blood-sugar swings that used to trigger crashes, according to r/LongCovid contributorsReddit

• A wellness-clinic roundup notes repeated patient reports of sharper focus and lighter brain fog after a few doses of GLP-1 drugs, including tirzepatideSanctuary Wellness Institute

Negatives

• Others hit a “sedative-like fatigue” after each injection that feels different from low-calorie tiredness and is hard to push throughReddit

• One Long COVID user says a single 2.5 mg dose caused the “worst reaction” they’ve ever had; five months later they were still recoveringReddit

• Persistent nausea, vomiting, and diarrhea mirror the common GI issues documented by GoodRx reviewers and leave some patients house-boundGoodRx

• Rapid weight loss led one patient to loose skin and stretch marks within two months, dampening enthusiasm despite symptom reliefThe Irish Sun

• An S4ME forum thread gathers disappointed ME /CFS users who saw “no magic cure-all” effect and stopped the drug after weeksScience for ME

Hurdles & Side Effects

• Insurance denials are rampant; r/Zepbound posters swap appeal tips after repeated “not medically necessary” rejectionsRedditReddit

• Even when covered, supply can be erratic because Eli Lilly is the sole legal supplier and prioritizes diabetes indicationsLilly Investor Relations

• Weekly self-injections bring needle anxiety, plus bruising and itching noted in official safety sheets and echoed by patientsCedars-Sinai Connect

• Severe GI upset forces some to juggle other meds—GoodRx warns vomiting or diarrhea can block absorption of oral drugsGoodRx

• Reports of gallstones or pancreatitis (confirmed by doctors in multiple Reddit threads) make certain long-haulers quit early out of cautionRedditReddit

• Facebook commenters who were already under-weight from chronic illness say they paused tirzepatide to avoid further muscle loss and malnutritionFacebook