Positives

• RAD-140 is sometimes brought up by patients who are worried about severe muscle loss, deconditioning, or inability to rebuild strength after Long COVID or ME/CFS (US Pharmacist).
• The theoretical appeal is muscle preservation, but this is not the same as treating PEM, autonomic dysfunction, immune activation, or brain fog (US Pharmacist).

Negatives

• There is no good evidence that RAD-140 improves Long COVID, ME/CFS, Lyme, POTS, MCAS, or chronic fatigue outcomes (US Pharmacist).
• Published case reports describe serious liver and cardiac injury signals, which is especially concerning for complex chronic illness patients (PMC).

Hurdles & Side Effects

• RAD-140 is an unapproved SARM and is associated with liver, cardiovascular, and hormonal risks (PMC).
• Patients should be especially cautious with unregulated products, contamination risk, and claims made by bodybuilding-focused vendors (US Pharmacist).