Positives

• MK-677 may be interesting to some Long COVID or ME/CFS patients because it is discussed around sleep depth, appetite, IGF-1, tissue repair, and muscle wasting (Healthy Male).
• For patients with poor appetite or illness-related weight loss, the appetite effect is the most understandable chronic-illness rationale (Wikipedia).

Negatives

• There is no established evidence that MK-677 improves PEM, brain fog, dysautonomia, MCAS, Lyme symptoms, or post-viral fatigue (WellnessPulse).
• Increased appetite, fluid retention, daytime grogginess, and glucose changes could worsen symptoms for some patients (Wikipedia).

Hurdles & Side Effects

• MK-677 is investigational and often sold through unregulated research-chemical channels (Healthy Male).
• Patients with diabetes risk, edema, heart issues, sleep disruption, or medication sensitivity should be especially cautious (WellnessPulse).