Positives

• Ligandrol is sometimes discussed by patients focused on severe muscle loss or rebuilding after prolonged inactivity from Long COVID or ME/CFS (Wikipedia).
• The possible appeal is anabolic support, but that is only indirectly related to chronic illness function and does not address PEM physiology (PMC).

Negatives

• There is no good evidence that Ligandrol treats Long COVID, ME/CFS, Lyme, POTS, MCAS, dysautonomia, or brain fog (WebMD).
• A strength-gain approach may be the wrong priority for patients who crash after exertion and need pacing before conditioning (USADA).

Hurdles & Side Effects

• Ligandrol is an unapproved SARM with product-quality, liver, lipid, cardiovascular, and hormone-suppression concerns (WebMD).
• Patients should be cautious about bodybuilding-focused information that does not account for PEM or autonomic instability (USADA).