Positives

• One patient on daily micro-dose troches from the Joyous program said they “made my brain fog non-existent” and that their “brain hasn’t been this clear in years” Reddit.
  
  
• After nearly a year of twice-weekly sublingual doses, one patient reported feeling “75% recovered,” with improvements in POTS, fatigue, and migraines Reddit.
  
  
• Several forum members described each infusion as a “break-through moment,” lifting ME/CFS-style cognitive fog and pain without worsening post-exertional malaise Health Rising.
  
  
• One Health Rising case report credited 800 mg infusions with cutting chronic-pain scores from 8/10 to 2–3 for weeks and “saving my life” in severe CFS Health Rising.
  
  

Negatives

• One long-COVID poster warned that “ketamine didn’t do ANYTHING for my LC symptoms—only depression,” noting they still lacked smell and taste Reddit.
  
  
• One ME/CFS user reported worse brain fog, memory lapses, and insomnia for up to 24 hours after each dose Health Rising.
  
  
• Twice-weekly IV trips left one patient “atrociously unwell” with rolling crashes despite mood improvements Health Rising.
  
  
• A long-term oral user (200 mg weekly) paused therapy after developing new cognitive problems and persistent fog Reddit.
  
  

Hurdles & Side Effects

• Clinics commonly charge about $2,250 for a six-infusion starter series (roughly $375 each) and require cash or financing Reddit.
  
  
• Severe exertion intolerance makes the 2-hour round-trip to infusion centers—and the need for a driver—unmanageable for some patients Health Rising.
  
  
• Acute effects patients mentioned include dissociation, vivid dreams, blood-pressure spikes, nausea, and a 24-hour “out-of-sorts” hangover Health Rising.
  
  
• Feeling “too good” after treatment can mask limits, and over-doing activity afterward often triggered post-exertional malaise Reddit.