Positives

• A patient took 1.5g fisetin in MCT oil and experienced a 70% improvement—the most energy in 6 months and the single most effective of 40+ interventions tried Reddit.
  
  
• A patient took 1,000mg/day of fisetin for 3 days and reported that a 2-year brain fog completely resolved Reddit.
  
  

Negatives

• A patient finished a bottle of fisetin and initially felt good but returned to baseline; repeating the protocol later had no benefit Reddit.
  
  

Hurdles & Side Effects

• Doctor’s Best Fisetin (Novusetin, 100 mg) runs about $0.55-0.61 per capsule on iHerb and Vitacost, while liposomal forms from Neurogan or Quicksilver Scientific cost roughly $30-50/month at general-wellness doses.
• Senolytic protocols call for 20 mg/kg pulse-dosed for 2-3 days monthly (about 1,400 mg/day for a 70 kg adult), which means 4-6 bottles of standard 100 mg capsules per cycle — patients usually switch to bulk powder or 500 mg caps to keep cost manageable.