Positives

• Heart-rate tamer: Many posters say a tiny 1 – 2.5 mg dose of bisoprolol “finally let me stand and walk without the 140 bpm spikes,” describing steadier pulse and less presyncope.Reddit

• Stamina bump & easier breathing: Several Long-COVID users report “more stamina and less breathlessness” once the drug capped their peak heart-rate during activity.Reddit

• Orthostatic relief for POTS-type symptoms: Threads on ME/CFS and dysautonomia forums note reduced orthostatic intolerance and fewer “head-rush” episodes after a few weeks on low-dose bisoprolol.Phoenix Rising ME/CFS Forums

• Fatigue scores drop in a small case-series: A Japanese case series of Long-COVID POTS patients found 94 % improved (fatigue, dizziness, HR) within ~5 months while on bisoprolol-based regimens. J Gen Fam Med PMC

• Asthma-friendly profile: Asthmatic Long-COVID patients describe tolerating bisoprolol better than non-selective beta-blockers, crediting its β-1 selectivity for “no lung flare-ups." Dinet

Negatives

• “No change at all”: A subset reports zero improvement in HR or symptoms after weeks on 1.25 mg, calling it “a dud.”Reddit

• Crushing fatigue & oversleeping: Multiple users describe the drug “doubling my sleep needs” or leaving them wiped out all day.RedditGoodRx

• Hair loss, muscle aches, persistent palpitations: These less-common but alarming effects push some to quit early. GoodRx

• Worsened shortness of breath or exercise intolerance: A few chronic-illness posters say bisoprolol “made walking harder” or deepened dyspnea until stopped.nhs.uk

• Rebound tachycardia on abrupt stop: Tapering stories warn that quitting suddenly can spike HR and anxiety “worse than before.”Reddit

Hurdles & Side Effects

• Early “wall” of dizziness, brain-fog, or nausea: Many need 1–2 weeks to acclimate; some can’t push through. Redditnhs.uk

• Bradycardia scares: Even micro-doses have driven resting HR into the 30s for a few patients, causing tinnitus and “space-out” sensations.Reddit

• Mood dips or “flat” affect: Hyper-adrenergic POTS users occasionally note new-onset low mood and switch to ivabradine or atenolol.Reddit

• Access delays: Long waits for dysautonomia or Long-COVID clinics mean some can’t get a script for months, relying on pacing alone.Reddit

• Tapering takes patience: Posters emphasize quarter-pill cuts over weeks to dodge withdrawal surges in HR and anxiety.Reddit