With many doctors, you have to go in with an arm pull studies. You have 15 minutes to make your case. LDN is possible b/c he also treat ME/CFS and fibromyalgia patients. I made the case for Metformin (Took six weeks to get used to it and after that, I am so grateful because of my pain is less now). Other symptoms I had: exercise and tolerance, muscle weakness, Severe cognition and memory, G.I. pain, elevated cholesterol, low white, blood cells, super low, ferritin, Extreme paranoia and rage. Prior, I was a healthy normal person who visited my doctor once a year.