Dr. John Haughton, MD, MS is the Medical Director of Renegade Research, a decentralized, patient-led non-profit organization focused on ME/CFS, Long COVID, and other post-infectious chronic inflammatory conditions. A longevity and Long COVID physician with a background in inflammaging, geriatric rehabilitation, accountable care organizations, and population health, Dr. Haughton recovered from his own two-year Long COVID experience in 2022 using a treatment framework grounded in what he calls a "hypoxic theory of disease" combining metformin, TLR4 quieting, microclot dissolution, NRF2 pathway promotion, and HIF1a limitation.